A complex community of microorganisms made up of bacteria, fungi, and other microorganisms-and their delicate balance-comprise the normal skin microbiota and contribute to the health and beauty of the skin.

The mechanisms of interaction between skin cells and microorganisms of the local microbiota are complex. One known mechanism is the recognition of microorganisms by skin cells through receptors called Pattern Recognition Receptors (PRRs).
When there is an imbalance (dysbiosis) in the skin microbiome, whether arising from environmental, chemical and/or physical challenges (UV radiation, heat, cold, dry environments, pollution and others), the barrier functions are compromised, leading to pH changes, decreased production of antimicrobial peptides, increased inflammation, and establishment of pathogenic microorganisms.

A healthy and functional skin barrier is an important protector against dehydration, penetration of pathogenic microorganisms, allergens, irritants, toxins, and radiation.

The term paraprobiotics refers to the use of inactivated microbial cells or cell fractions, containing components such as peptidoglycans, theichoic acids, surface proteins, and others, as well as crude cell extracts (complex chemical composition).

The use of paraprobiotics presents a number of advantages, such as: availability in their pure form, high stability and ease of inclusion in different matrices, specific mechanism of action, improved accessibility of microorganism-associated molecular patterns (MAMP’s) during recognition and interaction with pattern recognition receptors (PRR), ability to trigger specific responses directed by ligand-receptor interactions, and production of compounds beneficial to skin health.

Inactivated probiotics (paraprobiotics) naturally promote the rapid regeneration of the barrier function and the skin microbiome through their anti-inflammatory, antioxidant, anti-adhesion and antimicrobial properties, and stimulate colonization by beneficial health-promoting microorganisms.

Neoimuno® Skin Care paraprobiotics (MAMPs) are extracts derived from specific, concentrated cultures of microorganisms. They activate the innate immune response, strengthen the skin barrier, reduce damage to collagen, elastin and healthy cells, reduce inflammation and fight aggressions such as UV, pollution and stress.

Neoimuno® Skin Care solutions are a valuable alternative for use in formulations and products that contribute to skin health and beauty, and as an adjuvant in skin disorders, especially those associated with inflammatory processes.

• Due to their heat treatment for inactivation, MAMPs are ingredients of wider applicability since they do not present problems of shelf life and formulation incompatibility in final products.
• Ideal for topical applications in cosmetics and dermocosmetics.
• Stability of the ingredient without the need for refrigeration.